PRODUCT OF NATURAL ORIGIN,
CREATED IN A UNIQUE ENVIRONMENT OF RESPECT
 TO HUMANS, ANIMALS AND PLANTS

“Coupage”(blend) of Top Quality Olive Oil
TESTED IN HUMANS

PRODUCT OF NATURAL ORIGIN SUPPORTING IDEAL QUANTITIES OF ESSENTIAL
 BIOLOGIC NUTRIENTS BASED IN A RATIONAL MIXTURE (“coupage”)
 OF SEVERAL SPANISH ORGANIC EXTRA VIRGIN OLIVE OILS

 “oHo”
Contains oleic acid and other essential fatty acids, that are protected from oxidation
 through the balanced presence of polyphenols and vitamin E

 Its high content of cis oleic acid, together with the practical absence
 of trans fats, and its low content of waxes, makes “oHo” a nutritional product
 which is easily absorbed and assimilated by the body, thus providing new lipid cell
 self-renewal mechanisms as a well as a fat metabolism more resistant to oxidation

 “oHo”
interferes nutritionally with some of the inflammatory and
oxidising mechanisms that can cause arteriosclerosis





RATIONAL FOR ITS USE


For each 1mg/dL HDL-cholesterol blood increase the risk of Coronary Heart Disease (CHD) decreases 2 to 3%
[Gordon DJ, Rifkind BM. N Engl J Med 1989; 321:1311-6]

Only 5 (15%) out of 34 human studies with Olive Oil, show the capacity to
 increase HDL-cholesterol (“good cholesterol).
 Two of them were performed with “oHo” (see below, and www.bioaveda.com )

Increases of HDL-cholesterol (“good cholesterol”), and decreases of the
 total cholesterol/HDL-cholesterol ratio, are related to a lower risk of
cardiovascular events^1,2

RESULTS^3-6

 “oHo” intake for 30 days, at doses of 60 mL/day, increases significantly
 serum cholesterol-HDL in healthy persons and in patients at high cardiovascular risk

 “oHo”  intake for 30 days, at doses of 60 mL/day, decreases significantly the
 total cholesterol/HDL-cholesterol ratio in healthy persons and in patients at high cardiovascular risk

Hypoalbuminemia is (a) the most important cause and/or consequence
 of Malnutrition and Inflammation in patients with chronic kidney disease
 (b) a potent predictor of Cardiovascular Complications and Mortality in these patients^7-9

“oHo” intake for 30 days, at doses of 60 mL/day, increases significantly
serum levels of albumin and total proteins in patients at high risk of
 Malnutrition and Cardiovascular Disease

CONSTIPATION DISTURBS THE QUALITY OF LIFE OF HEALTHY PERSONS
 AND THAT OF PATIENTS AT HIGH RISK OF CARDIOVASCULAR DISEASE^10,11

“oHo” intake for 30 consecutive days, at doses of 60 mL/day, diminishes constipation
 significantly in healthy persons and in patients at high risk of Malnutrition and Cardiovascular Disease

References:
1. Boden WE. Am J Cardiol 2000; 86 (12A):19L. 2. Castelli WP, et al. Ann Epidemiol 1992; 2:23.
3. Pérez-Bañasco V, et al. World Congr Nephrology 2007; abstr T-PO-1316.
4. Villarrubia VG, et al. Nefrología 2007; 27:122. 5. Pérez Bañasco V, et al. Nefrología 2007; 27:472.
 6. Villarrubia VG, et al. Anales Científicos (BBAA) 2007; 1:6-15. 7. Kalantar-Zadeh K, et al. Am J Clin Nutr 2005; 81:543.
 8. Cooper BA, et al. Am J Kidney Dis 2004; 43:61. 9. Danielski M, et al. Am J Kidney Dis 2003; 42:286.
 10. López Cara MA, et al. Rev Esp Enf Dig 2006; 98:449. 11. Wu MJ, et al. Am J Kidney Dis 2004; 44:322.

BIOAVEDA, s.l
Research, Development & innovation
Jaén, Andalousia, SPAIN
www.bioaveda.com
Email:villarrubia@bioaveda.com

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